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Targeting genome alterations in human cells & model organisms. 

State-of-the-art, 4,200 ft2 Class 100 cleanroom equipped with over 40 pieces of process and analytical instrumentation for complex research projects that require micro and nanoscale fabrication. Technical expertise, foundry services, and use of equipment is available for dicing, stress measurements, deposition, deep silicon etch and photolithography.

Supporting research in microelectronics, electronic materials, nanotechnology, MEMS, biomedical and optical devices. Our staff provides professional suggestions and ideas to lab users on their projects, including planning, design, and integration for fabricating devices. Features Class 100 Cleanroom.

Device design, fabrication process formulation, photomask layout advice, and prototype testing utilizing traditional and novel approaches to microfabrication and nanofabrication of electronic devices, sensors, microfluidic devices, and nanomaterials test structures.

NIH-funded Center as one of five centers in the US to make up the National MMPC Consortium that specializes in sophisticated physiological procedures and instruments to characterize mouse models of obesity, diabetes, and its complications.

The Center consists of the following five phenotyping Cores:

• Metabolism Core uses in vivo metabolic procedures and instruments to assess energy balance, insulin sensitivity and glucose metabolism, and conducts drug trial studies.
• Analytical Core uses high throughput instruments to measure serum and tissue levels of metabolites, hormones, and cytokines.
• Islet Core uses in vivo and in vitro procedures to measure pancreatic function and insulin secretion.
• Cardiovascular Core uses in vivo imaging system to assess cardiac structure and function, and vascular phenotypes.
• Microbiome Core uses fecal collection and antibiotic treatment for gut microbiome analysis. 

Neuroradiology facility that offers the latest technology in image-guided intervention in developing minimally invasive treatments. 

Interdisciplinary robotics testing, research, and training facility that evaluates robotic capabilities, human performance, and human-robot interaction. Additional resources include Motek M-Gait instrumented treadmill with motion capture (Qualisys and Motion Analysis), a variety of biometric sensors, and NIRx functional near-IR spectroscopy.

Provides Next-Generation DNA & RNA sequencing services and technical expertise including NGS library prep, DNA and RNA quality assessment, Fluorometric quantification of DNA/RNA/Protein, DNA & RNA isolation, PCR/qPCR, Qubit fluorometry, gene expression & drug development studies. 

The facility provides high field NMR instruments and expertise to elucidate molecular structure, conformation, dynamics and interactions. 

A new, state-of-the-art JEOL 400 MHz NMR equipped with autosampler and automatic tuning & matching. The instrument can perform temperature and kinetic studies as well as x-nuclei and 2D experiments. Self-use and service work are available. 

Isolates bioactives by supercritical CO2, concentrate bioactives by reverse osmosis, thermally treat by ultrahigh pasteurization and agitating retort, produce emulsion systems by homogenization and encapsulate by freeze or spray drying. 

Optical Xenogen IVIS 100 imager & Spectrum CT Imager for in vivo detection and quantification of cells. 

Northeast hub for PacBio work utilizing PacBio Sequel. Services include sample quality control and assessment, SMRTBell library construction and validation (genomic, amplicon, RNA, targeted) , sequence analysis using 8M SMRTCells, and a variety of data analysis services (including ROI/CCS analysis, Iso-Seq analysis, HGAP assembly, DNA modification and motif detection, and custom applications). 

Offers a full range of proteomic services using an Orbitrap Fusion Lumos Tribrid MS including sample preparation, bottom-up protein identification, quantification of expression levels using both label-free and TMT multiplexing strategies, PTM analysis, 2D fractionation, and top-down proteomic analysis.

Clinical and basic research support in biostatistics, experimental design, data analysis, and data management. 

Provides controlled radiation environments and analytical measurement services and facilities for proton, neutron and gamma environments. 

State-of-the-art single photon computerized tomography (SPECT), positron emission computerized tomography (PET) & X-Ray computerized tomography (CT) cameras for imaging small animals.

Distribution of clones from both the Open Biosystems human & mouse shRNA lentiviral libraries and the Mammalian Gene Collection cDNA library. 

Provides a unique set of custom, moving web-based tools for the translation of advanced materials and nanomanufacturing processes to industrially relevant scalable platforms for the development of next generation life science innovations. 

The Hitachi SU-5000 field emission SEM is a microscope used to observe micron/nano-scale structures (resolution of 0.5 nanometer (10-9 m)). The FESEM is equipped with a deceleration mode for improved imaging and avoiding the effects of charging. The SEM is equipped with a secondary electron detector, backscatter detector and an additional STEM detector. 

Advanced quantitative light microscopy including super-resolution (SIM/ PALM), multi-photon, TIRF, confocal, and live-cell imaging. 

Micro assembly, prototyping, and integration for RF, wire bonding, optics, PCB and wafer/die attach applications. 

Support for conducting basic and translational research on mouse and human skin including acquisition of human skin, skin fluid, or skin cells for translational assays such as flow cytometry, ELISA, or single cell RNA sequencing. 

Develop high-throughput screens to discover novel drugs & chemical probes utilizing in house 1M compound collection & detection technologies. 

90,000 – gallon acoustic – optic test tank designed for development and testing of underwater measurement concepts and devices. 

2,200 square foot lab allows scientists to conduct research on living marine and estuarine organisms under controlled conditions. 

Structural characterizations, including molecular modeling, small molecule docking and inhibitor design (using the Schrodinger structure based drug design suite), crystallographic studies, organic synthesis and characterization, structure activity relationship (SAR) and chemistry support. 

A complete thermal analysis suite including Discovery TGA, Discovery DSC, Q800 DMA, and Instron 4466. Service level work and technical expertise are also provided. 

Open access biorepository provides a dynamic collection, storage and distribution service for human samples. 

State-of-the-art dual-source Bruker D8 Venture single-crystal diffraction system. Services include crystallization, data collection and structure determination.